They'll be joined by at least a dozen other high schools in the region.
In Appleton, students tell us they want to have their voices heard and be part of a historic movement.
They say they want to be able to tell their kids they helped do something about gun violence in schools.
In response, the Appleton Area School District says it's up to the students’ parents to decide if the children’s absence is ok.
If students don't get permission, the walkout will be considered unexcused.
"When I’m older maybe it will be different and these shootings won't be so common and I can tell my kids hey I did a walkout for that," said one student.
The Ashwaubenon School District is handling the walkout a little differently.
In a statement, the district superintendent said, "We strongly feel that it is important for our students to be able to practice their first amendment rights and share their voice on topics they are passionate about."
They'll allow for an optional walkout for the students with social workers and psychologists available as resources.