The 38 year old woman inside the sedan was ejected, suffering severe injuries. She was taken to the hospital. The 33 year old man suffered less severe injuries. It is unknown who was driving the vehicle. Both passengers are from Antigo.
Crews have re-opened both lanes at WIS 15 and 45 after closing them for multiple hours overnight.
The Outagamie County Sheriff's Department and the Hortonville Police Department responded to the crash.