UPDATE #2: One person was taken to a local hospital where they later died.
Deputies say they do not believe alcohol or drugs were a factor in the crash.
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UPDATE: All lanes of Highway 172 are now open following a crash, according to the Brown County Sheriff's Office and WisDOT.
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ORIGINAL REPORTING: Highway 172 at Webster is closed due to a crash, according to the Brown County Sheriff's Office.
Traffic is being rerouted up onto Webster, deputies say.
WisDOT says the closure is estimated to last for 2 hours.